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7.11. MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons

AP Abreu , CA Toro , YB Song , VM Navarro , MA Bosch , A Eren , JN Liang , RS Carroll , AC Latronico , OK Ronnekleiv , CF Aylwin , A Lomniczi , S Ojeda , UB Kaiser

J Clin Invest. 2020 Aug 3;130(8):44864500. 10.1172/JCI136564. PMID: 32407292 https://www.jci.org/articles/view/136564In brief: This study in rats and non-human primate models investigated the mechanisms by which MKRN3 regulates pubertal onset in rats and non-human primates.Comment: Pubertal timing is in...

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ey0019.7-7 | Basic Science | ESPEYB19

7.7. Connecting nutritional deprivation and pubertal inhibition via GRK2-mediated repression of kisspeptin actions in GnRH neurons

C Perdices-Lopez , MS Avendano , A Barroso , F Gaytan , F Ruiz-Pino , MJ Vazquez , S Leon , YB Song , V Sobrino , V Heras , A Romero-Ruiz , J Roa , F Jr Mayor , C Murga , L Pinilla , UB Kaiser , M. Tena-Sempere

Metabolism. 2022 Apr;129:155141. doi: 10.1016/j.metabol.2022.155141. Epub 2022 Jan 22. PMID: 35074314. https://www.metabolismjournal.com/article/S0026-0495(22)00019-1/fulltextBrief Summary: the authors used pharmacological and transgenic models to demonstrate the role of GRK2, G protein coupled-recept...

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ESPE Yearbook of Paediatric Endocrinology

7.11. MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons

7.7. Connecting nutritional deprivation and pubertal inhibition via GRK2-mediated repression of kisspeptin actions in GnRH neurons

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